Nucleotide Excision Repair: From Molecular Defects to Neurological Abnormalities

Molecular mechanism of nucleotide excision repair.

From its very beginning, life has faced the fundamental problem that the form in which genetic information is stored is not chemically inert. DNA integrity is challenged by the damaging effect of numerous chemical and physical agents, compromizing its function. To protect this Achilles heel, an intricate network of DNA repair systems has evolved early in evolution. One of these is nucleotide ex...

Human nucleotide excision repair syndromes: molecular clues to unexpected intricacies.

INTRODUCTION THE DEVELOPMENT and maintenance of life has critically depended on the evolution of mechanisms that ensure genetic integrity and stability. DNA, the vital carrier of genetic information, is continually subjected to undesired chemical alterations. Numerous environmental or endogenous compounds and various types of radiation, such as X-rays and ultra-violet (UV) light, induce a wide ...

Prokaryotic nucleotide excision repair.

Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches around the globe that inflict harsh environmental damage to their genetic material. NER is remarkable because of its diverse substrate repertoire, which differs greatly in chemical composition and structure. Recent advances in structural biology and single-molecule studies have given great insight into th...

SnapShot: Nucleotide Excision Repair

Nucleotide Excision Repair from Bacteria to Humans: Structure–Function Studies

T.M. Penning (ed.), Chemical Carcinogenesis, Current Cancer Research, DOI 10.1007/978-1-61737-995-6_13, © Springer Science+Business Media, LLC 2011 Abstract This chapter describes our present knowledge of nucleotide excision repair (NER) in both prokaryotic and eukaryotic organisms. NER is a generalized repair system capable of removing a wide range of DNA lesions differing in their shape and c...